Tissue Lysates
Cayman Chemical SynthetIc CarubIcIn 1mg
An anthracycline with anticancer activity; cytotoxic to MCF-7 and K562 cells (IC50s = 90 and 60 nM, respectively), as well as P-glycoprotein-expressing MCF-7/DOX and K562i/S9 cells (IC50s = 90 and 60 nM, respectively)
Cayman Chemical 1 3DIpalmItoleoyl Glycerol 1mg
A diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions; selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively); has been used in the formation of lipid bilayers to study the effects of membrane composition and valinomycin on membrane potential
Cayman Chemical 1 3-DInonadecnoyl Glycerol 1mg
A diacylglycerol; has been used as a standard in the quantification of diacylglycerols in synthetic milk fat by SPE/HPLC/ELSD
Cayman Chemical 2R-Glycerol-OD-galactopy 1mg
A substrate for β-galactosidase, the lactose repressor, the galactose-binding protein, the β-methylgalactoside transport system, and thiogalactoside transacetylase
Cayman Chemical HG-10-102-01 1mg
An inhibitor of LRRK2 (IC50 = 20.3 nM); also inhibits G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively); brain penetrant and inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2
Cayman Chemical 1-ArachIdonyl Glycerol 1mg
An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor; 2-AG undergoes rapid isomerization to 1-AG, which makes it a frequent contaminant in synthetic 2-AG preparations, markedly reducing their cannabinergic potency
Cayman Chemical SynthetIc Thujopsen 1mg
A sesquiterpene with diverse biological activities; inhibits Na+/K+-ATPase (IC50 = 25.9 UG/ml) and CYP2B6 (Ki = 0.8 µM); active against S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 UG/ml); inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 µM); cytotoxic to A549 cells (LC50 = 35.27 UG/ml); induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 UG/cm2, respectively)
Cayman Chemical SynthetIc GosypetIn 1mg
A flavonoid with diverse biological activities; inhibits MKK3 and MKK6, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells at 20 µM; scavenges DPPH radicals and inhibits copper-induced lipid peroxidation in cell-free assays; reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis at 10 mg/kg
Cayman Chemical 2C-I-FLYhydrochlorIde 1mg
An analytical reference standard categorized as a phenethylamine; induces the head-twitch response in mice; intended for research and forensic applications
Cayman Chemical SynthetIc Curzeren 1mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical SynthetIc SpongosIn 1mg
A nucleoside with diverse biological activities; antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors); inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM; decreases contractile force and frequency in spontaneously contracting isolated guinea pig atrial muscles (EC50s = 32.7 and 127.7 µM, respectively)
Abcam 4-Di-2-ASP, Cationic mitochondrial dye, 5G
MW 394.29 g/mol, Purity >97%. Photostable dye, which is nontoxic to cells and has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Mitochondrial Complex V ATP
A Cdk4 inhibitor (Ki 0.6 nM for Cdk4/cyclin D1) selective for Cdk4 over Cdk6 (Ki 13.9 nM for Cdk6/cyclin D3) increases senescence in HR HER2- breast cancer cells in vitro but does not induce cell death in combination with fulvestrant
Cayman Chemical MItochondrIal FUSN PROMTR 50mg
A promoter of mitochondrial fusion; induces elongation of mitochondria in Mfn1-/- or Mfn2-/- MEFs (EC50s = 5.3 and 4.42 µM, respectively); protects against MPP+-induced mitochondrial fragmentation and cytotoxicity in SH-SY5Y cells at 5 µM; reduces apoptosis and inhibits decreases in testosterone levels induced by triphenyl phosphate in TM3 cells at 1 µM; improves novel object recognition deficits in a rat model of doxorubicin-induced chemobrain at 2 mg/kg